Gene Regulatory Network of TF family AP1 in human
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
16→JUN: TOM1, BATF, MAP4K1, ZNF480, GLRX, APEX1, NTRK2, OSM, PKD1, MAPK1, MAPK3, MAPK11, ZNF253, BDK, RB1, NXN.
5→JUN + JUND: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5.
FOS→13: , CDK5, GSTP1, HLA-DPB1, HLA-DRA, HSPA1A, ITGA5, KRT6A, MSR1, NOS1, NTF3, BGLAP, SRR, CA2.
JUN→199: EGR1, ESR1, ETS2, HOXA5, SMAD7, MYB, MYC, ATF3, NFKB2, POU1F1, PPARA, RELB, SPI1, STAT1, TCIRG1, GNLY, FGL2, PRSS21, IL24, EMILIN1, CHGA, SEC6L1, CLU, CCR5, CCR7, ADH4, COL1A1, COL1A2, COL3A1, CR2, CSF1R, CSF2, MGAT5B, CSTB, CYP11A1, CYP19A1, CYP27B1, DBH, ACE, DDIT3, DEFB4, PSORS1C2, DMD, DPYD, AGTR2, ABCA1, ACSL3, FASN, ALDOA, FN1, FOLH1, GALC, AMD1, GBA, GFAP, GGT1, GJA1, GJB2, GM2A, GNRH1, GNRHR, GUCA2B, GYG, HBA1, HEXB, HFE, CD209, HLA-A, HLA-B, HLA-C, HMBS, HMGA1, HMOX1, AIRE, HRH1, TNC, ICAM1, IFNB1, IFNG, IGF1, APOE, IGFBP2, APP, FASLG, IL2RB, IL7R, ITGA6, ITGAX, JAK3, KCNMB1, KCNN3, KRT18, LAMA3, LBP, LCP1, LOX, MAOB, MAT2A, MDM2, ME2, MEP1B, MET, MGP, MHC2TA, MMP7, MMP9, MMP12, MMP19, MTHFR, MUC4, NCL, NGFB, NHLH2, NOS2A, NPY, NPPA, ATP2A2, NRAS, NTRK1, NTRK3, OAS2, OXT, OXTR, SERPINE1, SERPINB2, NIN, IER5, PDYN, ABCB1, PLA2G4A, TLR9, POLA, POLD2, AVP, PPP4C, PRKCB1, LENEP, ACAS2, PRL, PRNP, PSAP, PTGS1, PTX3, BCHE, RBP4, BDKRB1, CCL2, CCL4, CCL7, SELE, SLC3A2, SLC6A4, SLC6A6, SLPI, SOD1, SOD2, SPP1, SPRR1A, SPRR1B, SPRR2A, TBXAS1, TRB@, TFF1, TFF3, TFRC, TH, TIMP2, TLOC1, TNF, UBTF, SCGB1A1, UGT2B17, VAV1, VCAM1, VDR, VEGF, VIP, TFPI2, BFSP2, NR0B2, PEX3, RUNX2, PDE5A, TNFSF10, CBS, TNFRSF10A, CCK, CCND2, NAT1, DNAJA3, CD5, CD22, CD163, CD80, TNFRSF8, CD44, CD79A, CDC42, FGFBP1.
FOS + JUN→28: ETS1, PGR, TP53, CYP1A2, EDN1, ELN, ERCC1, HBB, FAS, IL12B, KRT16, MMP1, MMP2, MMP3, MMP13, MT2A, PDHA1, PENK, PLAUR, POMC, SNFT, PTGDS, PTGS2, SPRR3, TGFB1, TNFAIP6, TSHB, CD69.
Gene Regulatory Network of TF family AP1 in mouse
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
8→Jun: Mcf2, Mcf2l, Ngfr, Prkce, Pkd1, Ep300, Batf, Jundm2.
Jun→109: Bcl3, Egr1, Egr2, Msx1, Myb, Ppara, Relb, Sfpi1, Trp53, Emilin1, Rdh1, Ifna, Acp5, Crisp1, Prdx3, Prdx6, Fabp4, Apoa1, Apoc3, App, Atp2b1, Atp10a, Bcl2a1a, Bdkrb1, Cacna1e, Ccnd2, Cd5, Cdk5, Cftr, Col5a1, Col7a1, Col1a1, Crabp1, Csf1, Cspg3, Ctsl, Cyp11a1, Dbh, Ecm1, F3, Fgfr1, Fgl2, Gad1, Gba, Gja5, Gnrhr, Gria2, Nr3c1, Gstm1, Gzmb, H2-Aa, H2-D1, Hbegf, Hfe, Slc6a4, Elavl1, Ifnb1, Il13, Il5ra, Il7r, Il9, Klf1, Klf4, Klra1, Ldb1, Ltf, Met, Mmp2, Mmp3, Mmp9, Mt3, Nudt1, Muc3, Myod1, Nat2, Nfatc1, Nos2, Nr4a2, Tnfrsf11b, Pah, Prkar1b, Prh1, Ptgs1, Ptgs2, Rdh6, Cxcl2, St8sia4, Slc20a1, Sstr5, Serpina1, Spp1, Sdc1, Sdc4, Tapbp, Tesk1, Tff3, Timp3, Tlr4, Tnfrsf8, Ttr, Ucp2, Vegfa, Ifnt1, Ifi202b, Mapk3, Mrpplf3, Krt1-12, Rdh7, Btbd14b.
Fos + Jun→8: Igk, Crh, Fasl, H2-K1, Hmox1, Ngfa, Timp1, Vim.
Gene Regulatory Network of TF family AP1 in rat
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
Jun→92: Ar, Myb, Madh7, Slc5a5, Tnc, Slc15a1, Nr0b2, LOC191574, Aldh1a1, Aldoa, Aldoc, Atp1a3, Cftr, Cyp11b1, Cyp1a1, Drd1a, Edn1, Eno2, Gh1, Gja1, Got1, Gsta2, Gstp1, Hrh1, Hmgcs2, Hmox1, Il1a, Ins1, Me1, Mup1, Nos2, Nppa, Odc1, Penk1, Pomc2, Prnp, Ptgs1, Scg2, Scnn1b, Ccl2, Slc9a3, Sod2, Tac1, Tat, Kng1, Cyp2c40, Andpro, Gnrh1, Ccnb1, Igfbp5, Sec6l1, Bglap2, Slc2a2, Spp1, Vcam1, Cd44, Gss, Icam1, Sepw1, Tff3, Trh, Scgb1a1, F3, Igfbp1, Pcna, Cyp3a11, Cyp4f5, Udpgtr2, Gal, Pdyn, Hfe, Plcb3, Col1a1, CysS, Gclm, Mup5, Crygb, Mup4, Fert2_predicted, Chat, Fasn, Cd5, Espn, Lxn, Tgfb1, Cd14, Itgax, Ndr4, Gnrhr, Mmp9, Thbd, Cyp2c23.