Gene Regulatory Network of TF family ETS in human
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
10→ETS1: DAXX, FGF2, HGF, IL1A, PRKCA, SP100, TGFB1, UBE2I, MKNK1, RUNX2.
5→ETS2: ZMYND11, MAPK6, PTEN, RAF1, CDK10.
6→SPI1: NOTCH1, ID2, MECP2, RB1, SPIB, THPO.
5→ETS1 + ETS2: CREBBP, EP300, TTRAP, MAPK1, MAPK3.
ETS1→103: FOXD1, SMAD4, BCL2, BRCA2, TFAP2A, TOM1, SPRY2, CDKN1A, CDKN1B, FGL2, CHUK, COL1A2, COX4I1, PARP1, CSN2, CSNK2A1, CSNK2B, CTSB, DAD1, DDIT3, DNTT, SLC26A3, EIF4G1, ENG, F13A1, FCAR, GABPA, B3GAT3, GP9, GRPR, GZMB, CD209, HMOX1, BIRC2, TNC, ICAM4, KRTAP10-10, FASLG, IL10, IL13RA2, ITGA4, ITGA5, ITGB3, JAG2, KCNMB1, KDR, KIT, KRTAP10-12, LCK, LCP1, LTB, LTC4S, SH2D1A, LYZ, MAGEA4, MET, MPL, ABCC1, NNAT, NME1, NOS1, ATP2A3, NTHL1, SERPINE1, GP6, IER5, PDGFA, PECAM1, PF4, ABCB1, POLD1, POR, PPP2R4, AXL, PRL, REN, CCL3, CCL7, BID, BMP4, SLC19A1, TCN2, TRA@, TFRC, UGT8, VCAM1, VDR, CASP4, CASP8, SOCS1, TNFSF14, TNFRSF10B, TNFRSF10A, NRP1, CD5, CD8A, TNFRSF8, GMFG, CD79A, CD79B, CDC2L1, CDC2L2, FGFBP1.
ETS2→21: JUN, JUNB, MYBL1, CGA, CHRNE, CYP11A1, HBEGF, FGF1, GBA, IFNE1, KRAS, NTRK1, PDE7A, TLR9, CCND1, TERT, APPBP1, CCNA2, CGB5, CD34, CDC2.
ETV4→54: USF1, WT1, CETP, AGTR1, AGTR2, F9, AMD1, GGT1, GJB2, GNRHR, HFE, NRG1, HTR2A, APOH, IL4, IL8, IL13, LOX, LYN, MEP1B, NR3C2, MMP12, MMP13, MMP19, MUC4, NRGN, PLA2G4A, PLAUR, PSG1, PSG2, PSG3, PSG4, PSG5, PSG6, PSG7, PSG8, PSG9, PSG10, PSG11, BCHE, BDKRB1, SERPINB4, SCNN1G, SFTPD, SHMT2, SLC6A6, BST1, SYN2, TIMP2, TXN, VIM, LRP8, MADCAM1, DNAJA3.
SPI1→54: REL, CHI3L1, CLC, CSF1, CSF2RA, CTSK, CYBB, DAB2, PTCRA, ELA2, SERPINB1, FCGR1A, FCGR1B, FES, FOLR1, P2RY10, GPX1, HES1, ICAM1, IGJ, IL1B, IL1RN, IL3RA, IL8RA, ITGA2, ITGAM, ITGB1, ITGB2, LSP1, MPO, NCF1, NCF2, NCF4, ACP5, PPBP, PRTN3, B2M, RNASE2, S100A9, CCL5, SRF, TLR2, TYROBP, ZNF202, BLZF1, MCM3AP, CD22, CD33, SCARB1, SCARB2, CD40, G1P2, CD58, CD68.
ETS1 + ETS2→22: EGR1, MYC, TP53, CDKN2A, CSF2, FLT1, RNF11, ANGPT2, ANPEP, IL2, JAK3, KRT18, LIF, MDM2, ATP5B, PSEN1, PTHLH, TRB@, THBD, VWF, FOSL1, CD4.
ETS1 + ETV4→10: CDC37, ECE1, ERBB2, HPGD, MMP7, OAS2, PCSK6, RNF31, PTGS2, TIMP1.
ETS1 + SPI1→15: NFKB1, EBI3, CSF1R, IGHM, IL3, ITGA2B, ITGAX, LTF, MHC2TA, MME, MNDA, ABCB4, TLR4, WAS, CD53.
ETS1 + ETS2 + ETV4→9: FOS, HPSE, MGAT5B, MMP1, MMP3, MMP9, PLAU, SPP1, SURF1.
Gene Regulatory Network of TF family ETS in mouse
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
5→Sfpi1: Crebbp, Csrp3, Hmga1, Icsbp1, Trim14.
Etv4→28: Pax8, Cdc2b, Crisp1, Agtr2, Bdkrb1, Btk, Cbx2, Ccnd2, Cdc2a, Mia1, Fgfr1, Fgfr2, Fgfr3, Fgfr4, Gba, Gpx5, Hfe, Ldb1, Madcam1, Man2b1, Nsccn1, Pcna, Rpl32, Sat1, St8sia4, T, Vim, Zhx1.
Sfpi1→41: Bcl2, Myb, Nfkb1, Igk, Igh, Acp5, Aif1, Cd72, Csf1r, Ctsk, Dab2, Ela2, Enpep, Fcgr3, Gpd2, Gpx1, Gsc, Gypa, H2-Ab1, Hes1, Hgf, Igh-6, Igj, Il12rb1, Il4, Il5ra, Itgam, Itgb2, Ltf, Ly9, Slc11a1, Oprm1, Pip, Ptprc, Rb1, Tbp, Tlr4, Camk1d, Oscar, Olfm4, Prg3.
Ets1→43: Gata1, Myc, Tcrd-V, Kit, Nr2f2, Cdh5, Csf2, Pcyt1a, Ecm1, Fcgrt, Fgl2, Ggh, Elavl1, Cd79b, Il3ra, Itga3, Itgav, Itgb3, Kdr, Mef2a, Mmp14, Oprd1, Igbp1, Pkd1, Prkr, Prtn3, Pthlh, Sh2d1a, St6galnac1, Tcra, Dntt, Tgfbr2, Thy1, Tnfrsf10b, Tnfrsf8, Wap, Ifnt1, Ncdn, Zfp354c, Atp2a3, Rdh7, B3galt4, Cxcl4.
Gene Regulatory Network of TF family ETS in rat
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
Ets1→22: Cited2, Cdkn1a, Hgf, Pem, Nrp1, Prl, Tat, Thy1, Ucp1, Fgfr4, Ccnb1, Lhb, Casp3, Itga2b, Cox4i1, Pf4, Runx2, Cd5, Ccnd1, Znf354c, Mmp9, Vegf.
Etv4→10: Ggt1, Muc4, Serpine1, Scnn1b, Slc9a3, Avpr2, Plau, Syn2, Hfe, Hdh.