Gene Regulatory Network of TF family HIF in human
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
16→HIF1A: MLLT7, CITED2, MAPK14, ABL1, APEX1, HSPA4, IFNA1, IFNB1, IFNG, IL1B, HDAC7A, MAPK3, PTEN, CCL2, TGFB1, HSP82.
HIF1A→60: ESR1, NFKB1, PPARA, TP53, CDKN1A, CDKN1B, DDIT4L, ADFP, ADM, CREBBP, CYP2B6, EDN2, ENO1, EP300, EPO, ALAS2, ALDOA, FIGF, GAPD, HIG1, GBE1, E2IG5, GCK, B4GALT1, GPX3, HK1, HK2, HMOX1, ID2, IGFBP1, ITGB2, LDHA, MDK, NOS2A, NT5E, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PGK1, ABCB1, MIG-6, PPT1, PSEN2, BAX, CCND1, RORA, CCL16, CXCL12, SLC2A1, BNIP3, TERT, TF, TFF3, TGFB3, TIMP1, TRA1, TUFT1, HS2ST1.
ARNT→5: FOS, PGR, PGRMC1, ERO1L, TFF1.
HIF1A + ARNT→5: EDN1, LEP, TFRC, BHLHB3, BHLHB2.
HIF1A + EPAS1→5: FLT1, KDR, SERPINE1, VEGF, CA9.
Gene Regulatory Network of TF family HIF in mouse
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
Hif1a→45: Bcl2, Ppara, Trp53, Egln1, Cygb, Angpt1, Angpt2, Avp, Bax, Bid, Casp9, Cdkn1a, Ctsd, Dcx, Eno1, Epo, Fn1, Hk1, Hmox1, Itgb2, Krt1-14, Krt1-18, Krt1-19, Pfkfb3, Mmp2, Ndrg1, P4ha1, P4hb, Pdgfb, Pgf, Pgk1, Abcb1b, Plaur, Plod1, Cxcl12, Slc2a1, Bhlhb2, Tff3, Tgfb3, Car9, Map2k4, Plod2, Ep300, Gbe1, Ddit4.
Gene Regulatory Network of TF family HIF in rat
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
Hif1a→23: Wt1, Cebpd, Cdkn1a, Dusp1, Afp, Edn1, Epo, Gck, Hmox1, Mt1a, Nos2, Nppa, Serpine1, Pgk1, Pklr, Adm, Th, Plat, Adra1a, P4ha1, Tfrc, Alox15, Vegf.