Gene Regulatory Network of TF family NFKB in human
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
22→NFKB1: TOM1, CDKN2A, PRDX4, PARP1, NALP6,
UNC5CL, CARD8, GLRX, APEX1, LCP2, ARRB2, MAP3K1, PTPN6, RAC1, TNFRSF17, SFTPA1,
NXN, TLR3, TXN, ZAP70, PIR, TNFSF12.
18→RELA: PIAS3, PPP1R13L, CREBBP, EP300,
SIRT1, ABL1, HRAS, MDM2, NCF1, TTRAP, PML, PPP2R1B, PRKCI, PRKCZ, RFC1, BCR,
PIAS1, REPS2.
NFKB1→137: ELK1, ETS1, FOS, JUNB, MSX1, MYB, ATF3, BRCA1, BCL10,
SMC4L1, GNLY, SERPINA3, CCR7, MAP3K8, ADORA1, MAPK14, CSF1, CSN2, ADRA2B,
CYP11A1, CYP19A1, CYP27B1, AKR1C1, GADD45A, DEFB4, NQO1, DNASE1L2, DPYD, EDN1,
ENG, EPO, F8, PTK2B, FBP1, FCAR, FCGR3A, FYN, TINF2, GDNF, HLA-C, HLA-F, HMOX1,
HSD11B2, TNC, ID1, APOE, IGFBP2, IGHE, IGL@, KLK3, FAS, IL1A, IL1RN, FASLG, IL5,
IL10, ITGA6, IRF1, JAG2, KCNMA1, PPARA, LTA, LTB, LYN, MAT2A, MET, MMP1, MMP13,
MUC5B, MYOD1, ATP12A, NOS1, NPY1R, NR4A2, OAS2, OGN, RRM2B, PDCL, HERC5, PDE7A,
PDGFA, PDGFB, ABCB1, PLA2G2A, PLA2G4A, PLAUR, PLCD1, ACP5, PPP2R4, PRKCA, B2M,
PTAFR, PTGS1, PTHLH, PTPN13, REV3L, SAA1, CCL4, CCL11, CCL15, CXCL5, SDC4,
CARD15, SLC6A4, SLC11A1, SOD1, SPRR2A, BST1, TACR1, TFF3, THBD, TLR2, TOP1,
TRAF2, UGT2B17, VAV1, VEGF, VEGFC, VIM, VIPR1, VWF, TFPI2, MADCAM1, RIP, SYTL1,
TRADD, RIPK2, IER3, CCND2, DNAJA3, CD83, CD22, CD80, CD86, ABCG1, CD69, CD79A.
RELA→21: PGR, PPARA, PPARD, BCL3, CCR5, CTNNB1, AFP, AGT, HDAC1,
HDAC2, NR4A1, MEFV, MMP14, PCK2, TLR9, TRIB3, S100A6, CCL20, BLR1, SFTPA2,
CASP8.
NFKB1 + RELA→34: ELF3, AR, BRCA2, TP53, WT1,
EBI3, CFTR, COL1A1, COL1A2, CSF3, CTSB, A2M, FN1, GALR1, GSTP1, HLA-A, HLA-B,
BIRC2, BIRC3, APOC3, IL1R1, IL4, CXCL10, MICA, MMP3, MMP9, NOS2A, PTX3, CCND1,
SAA2, CCL3, CXCL11, TNFRSF10B, TNFRSF10A.
NFKB1 + RELA + REL→18: CRP, CSF2, F3, CXCL1, CXCL2,
CXCL3, ICAM1, IL1B, IL2, IL2RA, IL6, IL12B, IRF4, PLAU, PTGS2, CCL2, CCL5, TNF.
Gene Regulatory Network of TF family NFKB in mouse
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
6→Nfkb1: Mcf2, Adcyap1, Hcph, Mcf2l, P4hb, Vip.
14→Rela: Bcr, Abl1, Ahr, Ctla4, Cdc2a, Socs1, Crebbp, Ngfa, Prkcz, Pml, Tlr4, Akt1, Ing4, Pias1.
Nfkb1→61: Brca1, Pax8, Tal1, Irak2, Igh, Ifna, Acp5, Birc5, Apoa1, Apoc3, B2m, Blr1, Cacna1e, Ccnd1, Ccnd3, Mia1, Csf1, Csf2, Dnm1, Ptprv, Gad1, Gdnf, H2-Bf, H2-Ea, H2-L, Icam1, Ifngr2, Ii, Il15, Il1b, Il1rn, Il4, Il5, Irf1, Kdr, Madcam1, Mmp2, Mmp9, Nudt1, Muc3, Oprd1, Plau, Prkr, Ptger2, Ptgs1, Ptgs2, Rdh6, Ccl3, Ccl5, Sdc4, Tapbp, Tbxa2r, Ube2h, Ugcg, Vegfa, Vegfc, Prkwnk1, Ces2, Zfp354c, Gcs1, Nfkbiz.
Rela→14: Smad7, Ppara, Afp, Birc3, Birc2, Casp8, F3, Cxcl9, Gadd45b, Nfkbia, Pcna, Ccl2, Tnfrsf10b, Ep300.
Nfkb1 + Rela→15: Wt1, Igk, Akt1, Blk, Fas, Fasl, Cxcl10, Ifnb1, Il2ra, Il6, Atp12a, S100a4, Tert, Tnfsf15, Ebi3.
Nfkb1 + Rel + Rela→5: Myc, H2-K1, Il12b, Il2, Nos2.
Gene Regulatory Network of TF family NFKB in rat
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
5→Nfkb1: Prkcz, Tff3, Prkce, Rhob, Apex1.
Nfkb1→40: Brca1, Creb1, Tnc, A2m, Fgg, Gfap, Ifnb1, Igf2, Il1a, Il1b, Ldha, Ldhb, Mpg, Abcb1, Ptgs1, Scnn1b, Sod2, Pgy2, Cyp2c40, Spp1, Vcam1, Sele, F3, Igfbp2, Dbh, Cyp4f5, Pdyn, Adora1, Ptgs2, Ldhc, Ube2h_predicted, Gclm, Ldhd_predicted, App, Ccnd1, Lxn, Tgfb1, Mthfd1, Znf354c, Mmp9.
Nfkb1 + Rela→9: Ar, Adh1, Agt, Il6, Penk1, Tnf, Tnfsf15, Icam1, Pla2g2a.