Gene Regulatory Network of TF family Smad in human

Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.

Listing of the gene clusters (TFs are underlined):
SMAD1→18: COL1A1, AHR, FLNA, BAMBI, GNRHR, ID2, ID3, IGFBP3, LBP, TNFRSF11B, PDGFA, PDGFC, SPP1, TAGLN, TCF8, TGFBI, GDF15, ZFHX1B.
SMAD3→13: MYC, SF3B2, MIA2, COL6A1, COL6A3, CREBBP, DSPP, LAMC1, MMP9, MMP13, PEX6, EIF4ENIF1, ZNF198.
SMAD4→8: ESR1, ETS1, DACH1, FSHB, IHH, PTGS2, BGN, TITF1.

SMAD3 + SMAD4→18: HNF4A, AR, JUN, FSTL3, COL1A2, COL7A1, DOK1, ENG, EPO, MMP1, GADD45B, PTHLH, CCL2, SEPP1, VEGF, VIP, ZFP36, BTRC.

Gene Regulatory Network of TF family Smad in mouse

Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.

Listing of the gene clusters (TFs are underlined):
7→Smad1: Bmp3, Bmp1, Bmp2, Bmp4, Bmp5, Bmp6, Bmp7.

Smad1→10: Hoxc8, Amhr2, Col7a1, Gja1, Gpx4, Mmp13, Tagln, Timp1, Mixl1, Zfp354c.
Smad3→12: Bcl2, Myc, Acta2, Bax, Cdk2, Dspp, Pcna, Pex6, Sf3b2, Erbb2ip, Eif4enif1, Zfp198.

Smad3 + Smad4→8: Cebpb, Cebpd, Hnf4a, Pparg, Catnb, Gast, Itga5, Sstr2.

Gene Regulatory Network of TF family Smad in rat

Note:
Ellipses are TFs. Boxes are genes.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.