Gene Regulatory Network of TF family SP in human
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
SP1→295: CEBPD, ATF2, E2F1, EGR1, ELK1, ETS1, ETS2, FLI1, FOS, HIF1A, HNF4A, HOXA7, AR, JUN, JUND, SMAD2, SMAD3, SMAD4, MYBL1, MYBL2, NFKB2, LEF1, POU2F1, RARA, BCL2, REL, RELA, SPI1, BRCA1, TAL1, TP73, WT1, ADA, CDH3, HHLA1, SPRY2, CDKN1C, CEACAM5, CETP, CGB, FGL2, STARD3, SEC6L1, CHRNA3, CHRNA7, CLC, ADD1, ADH1A, ADH1B, ADH1C, ADH5, COL4A1, COL4A2, COL7A1, COL11A1, COX4I1, COX7A1, CPS1, CSH1, CSH2, ADRA1A, Trif, CTF1, CTGF, CTSD, ADRA2B, ADRB1, CYP3A4, CYP7A1, CYP19A1, CYP21A2, CYP27B1, DBH, DDX5, AGC1, DRD1, AGT, EDNRB, EGFR, ENG, EPO, EPOR, ALB, ALDH3A1, FASN, EFEMP1, FCAR, FES, ALDOA, NUP210, FN1, ALOX5, ALOX15B, ALPI, GAS, TINF2, GFAP, AMH, GH1, GJA1, GPC3, GLUD1, MCTS1, NR3C1, GSTA1, GUCA2A, GYPB, GYPC, HBE1, HBG1, HBZ, HK2, HLA-G, HMBS, HMOX1, ACACB, APBB1, HRAS, APEX1, HSD17B4, HSPA1A, HSPA8, HSPB1, HTR1A, HTR2A, HTR4, APOB, IFNG, IFNGR1, APOE, IGF1R, IGFBP2, APP, FAS, IL1A, IL1B, IL2, FASLG, IL2RB, IL3, IL3RA, IL10, IL13, IMPDH2, INSR, ITGA2, ITGAL, ITGAM, ITGAX, ITGB1, IVL, JAK3, JUP, KCNMA1, KIT, KRT5, KRT17, KRT18, KRT19, LDHA, LDHB, LHCGR, LOX, LTF, MCAM, CD99, NR3C2, MME, MMP1, MMP2, MMP9, MMP14, MNDA, MPG, ASS, MT2A, MUC4, NEFH, ATP1A3, NQO2, NOL1, NPY, NRGN, ODC1, OXTR, FURIN, PCSK6, PAFAH1B1, SERPINE1, SERPINB2, PCBD1, SERPINA5, PCK1, PDE6A, PDHA1, PGC, ABCB1, SERPINA1, PLAU, PLAUR, PNOC, POLB, DDIT4, PRKCA, PDGFC, PSEN1, PSG1, PTH, PTGS2, PTHLH, PTN, BAX, RAG2, RBP1, RBP4, RNU2, RPL10, RPS3A, BDKRB2, SCNN1G, CCL2, CCL3, CCL20, SFTPA2, SHMT2, SIAH1, ST8SIA1, SLC1A4, SLC5A1, SLPI, SOD1, SPN, SPP1, SPRR1B, SRC, STAR, BST1, VAMP2, TAF7, TCN2, ACTC, BUB1B, TERT, TGFA, TIMP1, TK1, TNNC1, TPI1, TTR, C8G, UBTF, UNG, VDR, VEGF, VEGFB, VIM, LRP8, MMP28, TFPI2, SLC19A3, COL18A1, MADCAM1, CAT, BLZF1, CAV1, SCARF1, RUNX1, TNFSF14, TNFRSF10B, TNFRSF10A, CCK, ST3GAL5, IER3, CCNA1, CCNB1, CCND2, CD5, CD7, CD9, CD19, CD22, CD163, ADIPOQ, CD28, TNFRSF8, CD33, SCARB1, GMFG, CD44, ABCG1, CD53, CD79A, CDC2, CDC25C, MVP.
SP2→6: NFATC2, PAEP, PLP1, CEACAM1, PAPSS2, PAPSS1.
SP3→32: CDH5, LECT1, CHI3L1, CTSB, DNASE2, ABCA1, ETF1, F2, F2R, F3, MSH6, ACACA, APOA1, TNC, IGFBP4, KLK3, IRF3, ITGAD, LHB, MYCN, NOS3, NPR2, PFKP, RET, SLC1A3, SLC9A3, BPI, TGFBR2, TLR2, CA9, MAP3K12, CALCR.
SP1 + SP3→57: ESR1, HOXB7, MYC, PGR, POU5F1, USF1, USF2, CDKN2B, CDKN2D, CHRNB4, COL1A1, COL1A2, COL2A1, CTSL, CYP1A1, CYP3A7, CYP11A1, CYP17A1, CYP26A1, CYP27A1, DKC1, AGTR1, DUX1, GLP1R, MAT2B, CXCL1, AOX1, HSD17B1, IGFBP1, IGFBP3, IL12B, ITGAV, KRT16, LCRB, LCAT, LIPE, LOR, LTC4S, MET, MIP, MUC2, MUC5AC, OPRM1, PDGFA, PDGFB, RORA, SOD2, BTK, TGFB1, TGM4, TIMP2, TNF, UTRN, FOSL1, HMGA2, EXO1, CD83.
Gene Regulatory Network of TF family SP in mouse
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
Sp1→156: Bcl3, Brca1, Hoxa4, Hoxb7, Msx1, Myc, Pax8, Rel, Sfpi1, Stat3, Tcrg, Dut, Htf9, Acta1, Adam17, Akp2, Prdx3, Birc5, Aprt, Rhob, Atp2b1, Akr1b7, Bak1, Bdkrb1, Bsg, Cai, Casp9, Cbx2, Ccnd1, Ccnd2, Ccnd3, Cd14, Cd24a, Cd34, Cd5, Cd8b1, Cdc25a, Cdh1, Chga, Chgb, Cited1, Ckmt1, Col4a1, Col1a1, Cox4i1, Csrp2, Ctsl, Dhfr, Dlx3, Slc26a2, Epor, Lcn5, Etsrp71, F3, Fasl, Fcgr2b, Fst, Gdnf, Ggh, Gstm2, H19, Hba-a1, Hck, Hdh, Hmbs, Hpn, Hras1, Hspca, Htf9c, Htr3a, Slc6a4, Iap8-1, Ifngr2, Cd79b, Ii, Il13, Il2, Il3ra, Itgav, Kit, Ldlr, Lgals1, Lhcgr, Ltf, Maz, Mbp, Mmp2, Mdh2, Mdh1, Mt1, Muc3, Myh1, Myh11, Myh2, Myod1, Ncam1, Nes, Neu1, Nf1, Nef3, Nqo2, Npr1, Odc1, Oprd1, Penk1, Per1, Prf1, Pgk1, Pkd1, Pkd2, Plat, Plau, Prm2, Prph1, Ptx3, Rag2, Rgn, Rps16, Scd2, St8sia1, St8sia4, Slc19a1, Slc2a4, Sstr2, Sstr5, Srf, Syn2, Tagln, Tapbp, Tbxa2r, Tead2, Thbs1, Tnfrsf10b, Tnfrsf8, Tyms, Ugcg, Vdr, Vim, Yy1, Prkwnk1, Cldn19, Mapk1, Mapk3, Ppia, Abcd2, Gyg1, Pttg1, Zfp354c, Tnfsf15, Hdac1, Dlc1, Atp2a3, Nup210, Adar, Cad, Setdb1.
Sp3→20: Acta2, Aebp1, Serpinh1, Cdkn1a, Csf1, Dnm1, Dnmt1, Fbln1, Gcgr, Gh, Gpx4, Klf4, Lama1, Ptpn1, Slc1a3, Vegfa, Ces2, Nr5a1, Reck, C1qtnf3.
Sp1 + Sp3→30: Pou5f1, Tal1, Ahr, Mmp28, Bax, Cdh5, Col7a1, Col1a2, Cyp26a1, Dck, Fas, Fgl2, Gp38, Il10, Abcc1, Mertk, Met, Mmp9, Muc2, Muc5ac, Oprm1, Ptcra, Ptger2, Rac2, Ren1, Ccl2, Six5, Tgm1, Tk1, Ftmt.
Gene Regulatory Network of TF family SP in rat
Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.
Listing of the gene clusters (TFs are underlined):
Sp1→122: Ar, Brca1, Egr1, Wt1, Madh3, Hif1a, Snurf, Cdkn1a, Ggt1, Lct, Ehhadh, Hadhb, Adra2b, Adra2c, Agtr1b, Aldoc, Atp1a1, Atp1a2, Atp1b2, Comt, Cyp1a1, Cyp2b1, Fbp1, Fgg, Gck, Gh1, Hmox1, Hras, Irf1, Mpg, Mt1a, Muc2, Mup1, Nppa, Tubb3, Omp, Serpine1, Abcb1, Pklr, Pnmt, Pomc2, Prl, Prnp, Prr1, Ccl2, Sod2, Agxt, Tac1, Tat, Ucp1, Pgc, Abcb4, Adrb1, Gipr, Crip, Apoa1, Adra2a, Th, Chrna3, Avpr2, Chrm4, Fgfr4, Ncl, Ccnd3, Gstt1, Pdgfa, Cox6a1, Tnfsf15, Lhb, Mist1, Casp3, Ctsh, Sepw1, Sstr4, Trh, F3, Adprt, Prkaca, Igfbp6, Fn1, Igfbp2, Ctsl, Igf1r, Apoe, Cyp4f5, Cyp2d10, Mrc1_predicted, Arg1, Serpine2, Col1a1, Adra1a, Hdh, Prps1, Crabp2, Htr2a, Atp2a2, Mup5, Lrp1_predicted, RGD1307599_predicted, Pck1, Cdk2, Chat, App, Cd5, Chrnd, Prkg1, Ccnd1, Dhcr7, Nrgn, Gapds, Srebf1, Znf354c, Apex1, Chrna1, Agtr1, Mmp14, Tfam, Cdkn1b, Nfl, Crot, Ptger4, Klf5.
Sp1 + Sp3→31: Pou5f1, Cited2, Dlk1, Acly, Aldoa, Atp1a3, Drd2, Hspa8, Me1, Abcc1, Myh11, Npr1, Odc1, Pdgfb, Pem, Slc2a1, Insr, Scarb1, Lhcgr, Scgb1a1, Pkm2, Cpt1a, Pyy, Sgk, Tgfbr1, Gja5, Kcnn3, Gp38, Egln3, Cd14, Mmp9.