Gene Regulatory Network of TF family p53 in human


Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.

Listing of the gene clusters (TFs are underlined):
21→TP53: PPP1R13L, BTBD14B, APEX1, IRF8, NSEP1, GTSE1, PIN1, ING3, PPM1A, PPP1CB, CARF, SSTR3, THRB, UBE2D2, UBE2D3, YY1, CUL5, PCAF, TNFRSF7, MAGED1, TNFRSF5.

TP53→262: CEBPA, E2F2, E2F3, E2F4, E2F5, EGR1, ESR1, ETS1, ETS2, FOXD1, FOS, MYC, ATF3, NFIC, NFKB1, BCL2, RELA, BCL3, BRCA1, BRCA2, STAT1, STAT3, TOPORS, ABCC4, TRIM22, PRG3, NDRG1, PIAS3, CDX1, HTATIP, SIVA, PLK2, CHEK1, CHEK2, BIRC8, TP53AP1, CHUK, CLK1, ABCC2, PLK3, KLF6, CSF1, CSPG2, CTNNB1, CTSD, DGKA, DGKB, DGKG, DDB2, GADD45A, AFP, ARID3A, DUSP1, EEF1A1, EEF1A2, EGFR, EPHA2, EIF4EBP1, HIPK1, ERBB2, AKT1, EZH2, FANCC, PTK2B, FBLN1, UNC5B, FBLN2, ALDH1A3, EFEMP1, FDXR, FKBP3, DKK1, KIN, P2RX2, FNBP4, PRG1, GAMT, GAS1, BBC3, SESN1, C20orf10, GCLM, GML, GPX1, RPA4, HD, HIC1, HLA-A, HLA-B, HMGN2, APAF1, APC, APCS, HRAS, BIRC2, BIRC3, HSPA1A, HSPA4, BIRC4, BIRC5, HSPCB, IGF1R, IGF2, IGFBP3, KLK3, TNFRSF6, IL1B, IL2, IL4, IL6, IL8, AQP1, IL11, IL15, IL15RA, JAK2, KAI1, APITD1, RHOA, STMN1, LGALS3, LIG1, LIG2, LIG3, LIG4, TACSTD1, MAP4, MCM2, MGMT, MIF, MKI67, MMP1, MMP2, MMP13, ABCC1, MSH2, JST, COX1, MUC2, BIRC1, NFATC4, NHLH2, NINJ1, NINJ2, NME1, NOS2A, NOS3, NTHL1, P2RX1, P2RX3, P2RX4, P2RX5, RRM2B, PCNA, POLK, LISCH7, PEG3, ABCB1, PIK3CA, PMAIP1, PML, POLD1, ATR, PPP1R7, PPP2R4, SMPD3, PRKAB1, MAPK1, MAPK8, MAPK9, PRODH, PSEN1, PCBP4, BAG1, PTGS2, PTHLH, BIRC6, BAI1, BAI2, BAK1, PTPN13, BAX, CARD12, RAD51, RAD51L1, ACTA2, RB1, CCND1, BCL2L1, RPS6KA1, BDKRB1, S100A4, S100B, CX3CL1, PERP, BLM, WIG1, SIAH1, SLC19A1, SMPD1, SMPD2, SOD2, SSTR2, SYK, TAF9, TBP, TBXAS1, BTG1, TERT, TFRC, TGFA, TGFB1, TGM1, TIMP3, TK1, TOP2A, TP53BP1, TUBA1, TYMS, TYR, TYRP1, WRN, XPC, XRCC5, BTG2, BIRC7, CALM2, PDRG1, CASP1, CASP3, SESN2, MAD1L1, CASP8, AMID, DGKE, DGKD, CDC14B, CDC14A, CAV1, ABCC3, TNFRSF10C, TNFRSF10B, TNFRSF10A, CFLAR, IER3, CCNA2, CCNA1, CCNB1, MBD4, CCNE1, CCNG1, CCNH, P2RXL1, PTTG1, TP53INP1, LITAF, GDF15, TP53I11, EI24, TP53I3, CDC25C, MVP.

TP53 + TP73→5: HIPK2, MDM2, THBS1, VEGF, CABLES1.

Gene Regulatory Network of TF family p53 in mouse


Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.

Listing of the gene clusters (TFs are underlined):
Trp53→108: Bcl2, Egr1, Fos, Foxo3a, Topors, Igfbp3q1, Igfbp3q2, Acta1, Akt1, Apaf1, Birc5, Aqp3, Rhoa, Rhob, Atm, Bax, Bdkrb2, Ccnd1, Ccng1, Kai1, Cdc25c, Cdc42, Cdkn1a, Chek1, Ckm, Plk3, Csnk, Csnk2a2, Cyp1b1, Gadd45a, Dnmt1, Eef1a1, Eef1a2, Egfr, Ei24, Epha2, Erbb2, Expi, Sesn1, Tnfrsf6, Fdxr, Gja5, Mr1, Hic1, Hipk1, Hras1, Inha, Irs3, Kit, Krt1-19, Stmn1, Bbc3, Mgmt, Mki67, Mmp2, Cd200, Nos2, Abcb1b, Abcb1a, Pik3ca, Pml, Prodh, Pten, Ptgs2, Rac1, Ret, Rnu6, S100a4, Siah1a, Siah1b, Siah2, Serpinb5, Dbpht1, Spp1, Tep1, Terc, Tert, Tnfrsf10b, Traf4, Tyr, Tyrp1, Upp1, Wrn, Gsn, Pias3, Sesn2, Scn3b, Gdf15, Cables2, Ing1, Mapk3, Ppia, Ccnb1, Card12, Polk, Gtse1, Fkbp3, Dbpht2, Chek2, Banp, Ramp2, Lrdd, Trp53inp1, Perp, Pdrg1, Letmd1, Glipr1, Sirt1.

Gene Regulatory Network of TF family p53 in rat


Note:
Ellipses are TFs. Boxes are genes.
Hexagons are the clustered genes. The number of the genes is shown inside.
Red lines indicate the protein-DNA binding is known.
Only official gene symbols are used in the network.

Listing of the gene clusters (TFs are underlined):
Tp53→28: Bcl2, Egr1, Myc, Cdkn1a, Cgrrf1, Rhoa, Eef1a1, Mpg, Cgref1, Mdm2, Pgam1, Abcb1, Bax, Pgy2, Pgam2, Ccnb1, Bdkrb2, Ephx1, Mgmt, Tnfsf6, Ccng1, Ddr1, Pcna, Slc6a6, Eef1a2, Atm, Unc5b, Apex1.