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NUMBER

GD_ME_MT_DE_G_D_N_0074-SK

DEFINITION

skeletal-muscle alpha-actinin, exon EF1bSK, chicken

REFERENCE

Parr, T., Waites, G.T., Patel, B., Millake, D.B., and Critchley, D.R., A chick skeletal-muscle alpha-actinin gene gives rise to two alternatively spliced isoforms which differ in the EF-hand Ca(2+)-binding domain. Eur J Biochem, 1992. 210(3): p. 801-9.

EXPRESSION

MT

REGULATORY FEATURES

encodes part of an EF hand that is involved in Ca++ binding

TEMPORAL REGULATION

usage of the exon increases during development

TECHNIQUE

PCR and sequencing

ACCESSION

X68799 S53137

SOURCE

genomic DNA

5' SCORE

5.32

3' SCORE

4.67

ACCEPTOR SITE

tttggtcaatag

EXON SEQUENCE

1 aggaagaacg gactgatgga ccatgatgat ttcagagctt gcttgatttc aatgggttat gatttg

DONOR SITE

gtatga

5' EXON

0 catatccgtg ttggatggga gctcctactt actaccattg ctcgaactat caatgaggtt gagactcaga tcctcacaag agatgccaag ggtatcaccc aggagcaaat gaatgacttc agagcatcat tcaatcattt tgacagg

3' EXON

1 ggtgaagctg agtttgctag aatcatgtcc ttggttgacc ccaatggaca aggaaccgtc actttccagt ccttcattga cttcatgacc agagaaacag cagatacgga cacggctgag caagtgatag cttccttcag aatcctggct tcagataag

DISEASE

COMMENTS

mutually exclusive to 0074-skv, muscle form, 3' exon exon EF2 has unusual aag 3' splice site

REVISION

This comment is added on 970314