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NUMBER
- HS_CA_MT_UU_U_D_N_0094-ex13
DEFINITION
- CD44, exon 13
REFERENCE
- Screaton, G.R., Bell, M.V., Jackson, D.G., Cornelis, F.B., Gerth, U., and Bell, J.I., Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci U S A, 1992. 89: p. 12160-4.
EXPRESSION
- expressed in a wide range of tissues
REGULATORY FEATURES
- nd
TEMPORAL REGULATION
- nd
TECHNIQUE
- cloning
ACCESSION
- L05418
SOURCE
- genomic
5' SCORE
- 5.06
3' SCORE
- 1.02
ACCEPTOR SITE
- tcattgaaacag
EXON SEQUENCE
- 3 agcagagtaa ttctcagagc ttctctacat cacatgaagg cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca
DONOR SITE
- gtaagg
5' EXON
- 3 ctattgttaa ccgtgatggc acccgctatg tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca cagacagaat ccctgctacc a
3' EXON
- 3 gagaccaaga cacattccac cccagtgggg ggtcccatac cactcatgga tctgaatcag atg
DISEASE
- disease
COMMENTS
- one of the most extensively spliced alternatively spliced genes, 12 out of 19 exons alternatively spliced; genomic organisation; described as exon B in: Cooper, D.L., Dougherty, G., Harn, H.J., Jackson, S., Baptist, E.W., Byers, J., Datta, A., Phillips, G., and Isola, N.R., The complex CD44 transcriptional unit; alternative splicing of three internal exons generates the epithelial form of CD44. Biochem Biophys Res Commun, 1992. 182: p. 569-78.
REVISION
- This comment is added on 970314 ;; line 1 modified 970107, 970108