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NUMBER
- RN_CA_UU_UU_G_U_N_0118-16
DEFINITION
- alpha amidating monooxygenase gene (exon 16)
REFERENCE
- Ouafik, L.H., Stoffers, D.A., Campbell, T.A., Johnson, R.C., Bloomquist, B.T., Mains, R.E., and Eipper, B.A., The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains. Mol Endocrinol, 1992. 6(10): p. 1571-84.
EXPRESSION
- predominantly used in atrium and brain
REGULATORY FEATURES
- governs sulfonation (see comment)
TEMPORAL REGULATION
- na
TECHNIQUE
- cloning
ACCESSION
- L01682
SOURCE
- genomic DNA
5' SCORE
- 5.24
3' SCORE
- 11.16
ACCEPTOR SITE
- tccccctcgcag
EXON SEQUENCE
- 2 gtgatttcta ttcactgctt tccaagctgc taggagaaag ggaagatgtt catgtgcaca agtataatcc tacagaaaag acagaatctg ggtcagacct ggtagctgag attgcaaacg tggtccagaa aaaggacctt ggtcggtctg acgccagaga aggtgcagag catgaggaat ggggtaatgc tatcctagtc agagacagga tccacagatt ccaccagcta gagtcaactc tgaggccagc tgagagcaga gctttctcgt tccagcagcc tggcgaaggc ccttgggaac cagaaccctc aggag
DONOR SITE
- gtgcat
5' EXON
- 2 cggcacttct agtgacgaaa tgtgtaacct gtacatcatg tattacatgg aagccaaata tgcactttcc ttcatgacct gtacaaagaa cgtggctcca gatatgttca gaactatccc agcagaggcc aatatcccaa ttcctgtcaa accggacatg gttatgatgc acgggcatca caaag
3' EXON
- 1 gttttattta ccacacggct tgagcataga tacagatgga aattattggg tcacagatgt ggctctccac cag
DISEASE
- na
COMMENTS
- Yun, H.Y., Keutmann, H.T. and Eipper, B.A. (1994) Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase. J Biol Chem 269(14): 10946-55. ;; Exon governs sulfonation: inclusifon of exon A results in sulfatation of 0-glycans.
REVISION
- This comment is added on 970314 ;; line 1 modified 970113 ;; items 5 and 18 updated by ss on Jan 08, 1998.