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NUMBER

HS_CA_UU_UU_G_U_N_0294

DEFINITION

vascular cell adhesion molecule-1, exon 5

REFERENCE

Osborn, L., Vassallo, C., and Benjamin, C.D., Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1. J Exp Med, 1992. 176: p. 99-107.

EXPRESSION

nd

REGULATORY FEATURES

nd

TEMPORAL REGULATION

nd

TECHNIQUE

cloning, immunostain

ACCESSION

M73255

SOURCE

genomic DNA

5' SCORE

7.04

3' SCORE

7.18

ACCEPTOR SITE

ttttccacctgtgtcccag

EXON SEQUENCE

3 agaaaccatt tactgttgag atctcccctg gaccccggat tgctgctcag attggagact cagtcatgtt gacatgtagt gtcatgggct gtgaatcccc atctttctcc tggagaaccc agatagacag ccctctgagc gggaaggtga ggagtgaggg gaccaattcc acgctgaccc tgagccctgt gagttttgag aacgaacact cttatctgtg cacagtgact tgtggacata agaaactgga aaagggaatc caggtggagc tctact

DONOR SITE

GTAAGT

5' EXON

3 tatcacccaa gaatacagtt atttctgtga atccatccac aaagctgcaa gaaggtggct ctgtgaccat gacctgttcc agcgagggtc taccagctcc agagattttc tggagtaaga aattagataa tgggaatcta cagcaccttt ctggaaatgc aactctcacc ttaattgcta tgaggatgga agattctgga atttatgtgt gtgaaggagt taatttgatt gggaaaaaca gaaaagaggt ggaattaatt gttcaag

3' EXON

3 cattccctag agatccagaa atcgagatga gtggtggcct cgtgaatggg agctctgtca ctgtaagctg caaggttcct agcgtgtacc cccttgaccg gctggagatt gaattactta agggggagac tattctggag aatatagagt ttttggagga tacggatatg aaatctctag agaacaaaag tttggaaatg accttcatcc ctaccattga agatactgga aaagctcttg tttgtcaggc taagttacat attgatgaca tggaattcga acccaaacaa aggcagagta cgcaaacact ttatgtcaat g

DISEASE

COMMENTS

gene structure, chromosomal localisation and sequence reported in: Cybulsky, M.I., Fries, J.W., Williams, A.J., Sultan, P., Eddy, R., Byers, M., Shows, T., Gimbrone, M.A., and Collins, T., Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc. Natl. Acad. Sci. U.S.A, 1991. 88: p. 7859-7863.

REVISION

This comment is added on 970314