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NUMBER

HS_CA_MT_UU_G_U_N_0456-189

DEFINITION

vascular endothelial growth factor (VEGF), 72 bp exon

REFERENCE

Houck, K.A., Ferrara, N., Winer, J., Cachianes, G., Li, B., and Leung, D.W., The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol, 1991. 5: p. 1806-14.

EXPRESSION

nd

REGULATORY FEATURES

putitative nuclear localisation signal

TEMPORAL REGULATION

nd

TECHNIQUE

cloning and PCR

ACCESSION

S85219

SOURCE

genomic DNA

5' SCORE

4.05

3' SCORE

NA

ACCEPTOR SITE

tccag

EXON SEQUENCE

2 aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag cgcaagaaat cccggtataa gtcctggagc gt

DONOR SITE

gtacgt

5' EXON

1 caaggccagc acataggaga gatgagcttc ctacagcaca acaaatgtga atgcag

3' EXON

2 atgtgacaag ccgaggcggt gagccgggct gga

DISEASE

nd

COMMENTS

only 5 nt of 3'splice site are given, VEGF isoforms containing this exons are not secreted but stay mostly cell -associated;; overview given in: Ferrara, N., Houck, K.A., Jakeman, L.B., Winer, J., and Leung, D.W., The vascular endothelial growth factor family of polypeptides. J Cell Biochem, 1991. 47: p. 211-8.

REVISION

This comment is added on 970314