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NUMBER

HS_CA_MT_DE_C_D_N_0545-HUM

DEFINITION

type II collagen gene, exon 2, human

REFERENCE

Metsaranta, M., Toman, D., de Crombrugghe, B., and Vuorio, E., Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing. J Biol Chem, 1991. 266: p. 16862-9.

EXPRESSION

in older fetus exon 2 is used in most non-chondrogenic tissues

REGULATORY FEATURES

might have a morphogenetic role in development

TEMPORAL REGULATION

expressed in prechondrogenic cells, during maturation of chondrocytes exon is no longer expressed,

TECHNIQUE

RNA in situ

ACCESSION

nd

SOURCE

cDNA

5' SCORE

NA

3' SCORE

NA

ACCEPTOR SITE

nd

EXON SEQUENCE

3 aggaggctgg cagctgtgtg caggatgggc agaggtataa tgataaggat gtgtggaagc cggagccctg ccggatctgt gtctgtgaca ctgggactgt cctctgcgac gacataatct gtgaagacgt gaaagactgc ctcagccctg agatcccctt cggagagtgc tgccccatct gcccaactga cctcgccact gccagtg

DONOR SITE

nd

5' EXON

1 atgattcgcc tcggggctcc ccagacgctg gtgctgctga cgctgctcgt cgccgctgtc cttcggtgtc agggccagga tgtcc

3' EXON

3 ggcaaccagg accaaag

DISEASE

COMMENTS

complete gene structure known, expression determined in: Lui, V.C.H., Ng, L.J., Nicholls, J., Tam, P.P.L., and Cheah, K.S.E., Tissue specific and differential expression of alternatively spliced alpha1(II) collagen mRNAs in early human embryos. Develop. Dynamics, 1995. 203: p. 198-211.

REVISION

This entry is modified on 970316; title line (item 2) was modified ;; item 15 was modified by M25698