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NUMBER

HS_A3_00_00_G_U_N_0558-a3

DEFINITION

ASF-2

REFERENCE

Ge, H., Zuo, P. and Manley, J.L. (1991) Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell 66(2): 373-82.

EXPRESSION

nd

REGULATORY FEATURES

frameshift, changes a downstream SR domain into a hydrophobic domain

TEMPORAL REGULATION

nd

TECHNIQUE

cloning

ACCESSION

M72709

SOURCE

genomic DNA

5' SCORE

NA

3' SCORE

-4.88

ACCEPTOR SITE

ttcaatggaaag

EXON SEQUENCE

1 TTCTGTCTAT CCAATAG

DONOR SITE

na

5' EXON

1 GGGGGTGGAG GTGGCGGAGC TCCCCGAGGT CGCTATGGCC CCCCATCCAG GCGGTCTGAA AACAGAGTGG TTGTCTCTGG ACTGCCTCCA AGTGGAAGTT GGCAGGATTT AAAGGATCAC ATGCGTGAAG CAGGTGATGT ATGTTATGCT GATGTTTACC GAGATGGCAC TGGTGTCGTG GAGTTTGTAC GGAAAGAAGA TATGACCTAT GCAGTTCGAA AACTGGATAA CACTAAGTTT AGATCTCATG AG

3' EXON

2 GGAGAAACTG CCTACATCCG GGTTAAAGTT GATGGGCCCA GAAGTCCAAG TTATGGAAGA TCTCGATCTC GAAGCCGTAG TCGTAGCAGA AGCCGTAGCA GAAGCAACAG CAGGAGTCGC AGTTACTCCC CAAGGAGAAG CAGAGGATCA CCACGCTATT CTCCCCGTCA TAGCAGATCT CGCTCTCGTA CATAAGATGA TTG

DISEASE

na

COMMENTS

no expression of this isoform could be detected in Northern blot, gene structure of flanking exons not clear

REVISION

created on Apr 18, 1998