modify this entry

---

NUMBER

MM_A5_MT_DE_C_U_N_0649-1

DEFINITION

mouse retinoic acid receptor a 1 , exon 1 and exon 2

REFERENCE

Leroy, P., Krust, A., Zelent, A., Mendelsohn, C., Garnier, J.-M., Kastner, P., Dierich, A., and Chambon, P., Multiple isoforms of the mouse retinoic acid receptor a are generated by alternative splicing and differential induction by retinoic acid. The EMBO Journal (1991) Vol 10 (1) : 59-69

EXPRESSION

Exons 1 and 2 (in mRAR-a1) was predominant in various stage embryos adult and fetal brains as well as skin, muscle, heart and kidney.

REGULATORY FEATURES

Exon 1 and 2 encode for the 5' UTR and the domain A1

TEMPORAL REGULATION

In adult tissues, the alternative form mRAR-a2 becomes predominant over mRAR-a1

TECHNIQUE

nothern

ACCESSION

X56572

SOURCE

cDNA

5' SCORE

NA

3' SCORE

NA

ACCEPTOR SITE

nd

EXON SEQUENCE

1 agtctagggc tccgggtaaa gtttcagcct ctgcacgtga ctcgccatgg ccgctgccgt cgccccgcgc ccctgagctg cggccccccg gacggctcct ctcggaggac cccacacccc tgacgccggg cagcgccgcg gccgctgctt ggggcagacc ctgtgcccgc agacacgcag acgggttgca tcccctcgct tcgagcacca caggacatgc ctccccccag ccacctacct ggggcccttc tgggagtggc atcctctttg ataccctgaa gaccagctct ggaccttcct acaaaagtgt ctcccaggac cgcttaacca aaggacggat tcttgggaca tcccccaatc cacctggccc ctccggctag ggagggggac ccagaagact aaagttgact aacttgggac ttgcagctcc agggacagaa gggggtgggg gtgggctgac cacccaaccc cccctctggg ccccccggcc ccatgccccg aggaagaggg actgcgtgaa ggccatcaca actacctgcc agactgtttg cctgctcttc tgactgtggc tgcttggcat ggccagcaat agcagttcct gcccaacacc tgggggcggg cacctcaatg ggtacccagt acccccctac gccttcttct ttccccctat gctgggtgga ctctccccac ccggcgctct caccagcctc cagcaccagc ttccagtcag tggttacagc acaccgtccc cagccaccat cgagacccag agcagcagtt ccgaagagat agtaccc

DONOR SITE

nd

5' EXON

na

3' EXON

0 ccatcgagac ccagagcagc agttccgaag agatagtacc c

DISEASE

nd

COMMENTS

Seven mouse RAR- a cDNA isoforms have been isolated, all having the 3'-exon 9 in common. ;; 3'-common exon is exon 9 (item 16)

REVISION

created on 970618