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NUMBER

MM_ME_TC_UU_C_U_U_0656-eta

DEFINITION

T-cell receptor CD3 eta chain

REFERENCE

Ohno, H., and Saito, T., CD3 zeta and eta chains are produced by alternative splicing from a common gene. Int Immunol, 1990. 2: p. 1117-9.

EXPRESSION

expressed in T-cells as part of a zeta/eta heterodimer

REGULATORY FEATURES

heterodimer structure maybe linked to inositol phospholipid hydrolysis and cell growth arrest

TEMPORAL REGULATION

nd

TECHNIQUE

screening of a genomic library

ACCESSION

M33158

SOURCE

cDNA

5' SCORE

NA

3' SCORE

4.79

ACCEPTOR SITE

cctcacaaacag

EXON SEQUENCE

1 gacagccact tccaagcagt gcagttcggg aacagaagag agagagaagg ttcagaactc acaaggaccc ttgggttaag agcccgcccc aaaggtgaaa gcacccagca gagtagccaa tcctgtgcca gcgtcttcag catccccact ctgtggagtc catggccacc cagtagcagc tcccagctct aaggccctgt gctcagctct ggtgatgacc ctggctgctg tcacatgagt tgtggtgagg atgggacttt tgaaaaatct gatgttccaa tttctttcat gcatgctcta ctcagaagtg agcaagggcc aaaactcctg ggcatgcatc tgaatgaatc tctcaactta gaaaagactt gcctgcccct ctgagctggc caggtgtccc cacctaccct ttggcatgcc tccaagtgcc aggacgccac agactgcatt ggggccgaag acttcccttt tctttggttt ttttgtttgt tttgagttta tacaatcatt aagaaatctt tggttttggc tggaaatgga aaaacaaaac aaatcaaaga aaccaccctc ccctggctta tagcagcagt attatgacct gacctggctg agctttcccc ccctccaact ttgggggtgg aaattgcaag ttaagaacta cattcaaaga aaacgttgaa agggccggag aagcagcttc cagaaagccc gtcggatata agattgtcaa ataataataa ctattattat aatatattaa taataaa

DONOR SITE

xx

5' EXON

2 aggcggagag gcaaggggca cgatggcctt taccag

3' EXON

1 cactgcagaa agacaagatg gcagaagcct acagtgagat cggcacaaaa ggcgag

DISEASE

COMMENTS

TC: T-cells; mutual exclusive to exon VIII of eta chain; zeta and eta chain derived from the same gene; contains polyadenylation signal

REVISION

This comment is added on 970314