modify this entry

---

NUMBER

MM_CA_KD_UU_C_U_Y_0691

DEFINITION

Evi-1

REFERENCE

Bordereaux, D., Fichelson, S., Tambourin, P., and Gisselbrecht, S., Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs. Oncogene, 1990. 5: p. 925-7.

EXPRESSION

the two forms are expressed in virus transformed cells as well as in kidney

REGULATORY FEATURES

exon deletion results in deletion of two of the 10 zinc fingers

TEMPORAL REGULATION

nd

TECHNIQUE

RNase protection, northern

ACCESSION

X54989

SOURCE

cDNA

5' SCORE

NA

3' SCORE

NA

ACCEPTOR SITE

nd

EXON SEQUENCE

3 gtgagggcaa gaaccatttt gcggcaggtg gattttttgg ccaaggcatt tcacttcctg gaacgccagc tatggataaa acgtccatgg ttaatatgag tcatgccaac ccgggccttg ctgactattt tggcgccaat aggcatcctg ctggtcttac ctttccaaca gctcctggat tttcttttag cgttcctggt ctgtttcctt ccggcttgta ccacaggcct cctttgatac ctgctagttc tcctgttaaa ggactatcaa gtactgaaca gacaaacaaa agtcaaagtc ccctcatgac acatcctcag atactgccag ctacacagga tattttgaag gcactatcta aacacccatc tgtaggggac aataagccag tggagctcca gcccgagagg tcctctgaag agaggccctt tgagaaaatc agtgaccagt cagagagtag tgaccttgat gatgtcagta caccaagtgg cagtgacctg gaaacaacct cgggctctga tctggaaagt gacattgaaa gtgataaaga gaaatttaaa gaaaatggta aaatgttcaa agacaaagta agccctcttc agaatctggc ttcaataaat aataagaaag aatacagcaa tcattccatt ttctcaccat ctttagagga gcagactgcg gtgtcaggag ctgtgaatga ttctataaag gctattgctt ctattgctga aaaatacttt ggttcaacag gactggtggg gctgcaagac aaaaaagttg gagctttacc ttacccttcc atgtttcccc tcccattttt tccag

DONOR SITE

nd

5' EXON

2 tcagttttca aacctttgcc gtcataagcg catgcatgct gattgcagaa cccaaatcaa gtgcaaagac tgtggacaaa tgttcagcac tacgtcttcc ttaaataaac acaggaggtt tt

3' EXON

3 cattctctca atcaatgtac ccatttcctg atagagactt gagatcgtta cctttgaaaa tggaacccca atcaccaggt gaagtaaaga aactgcagaa gggcagctct gagtccccct ttgatctcac cactaagcga aag

DISEASE

proviral integration (linkage to Evi-1) results in expression of the two isoforms and myeloid leukemia

COMMENTS

REVISION

This comment is added on 970314