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NUMBER
- HS_CA_MT_UU_G_U_U_0966-1
DEFINITION
- human parathyroid-hormone-related protein ( PTHrP ) , exon 1b
REFERENCE
- Suva, L.J., Mather, K.A., Gillespie, M.T., Webb, G.C., Ng, K.W., Winslow, G.A., Wood, W.I., Martin, T.J., and Hudson, P.J., Structure of the 5' flanking region of the gene encoding human parathyroid- hormone-related protein (PTHrP). Gene Vol 77:95-105
EXPRESSION
- PTHrP is produced in Cancers associatid with the HHM
REGULATORY FEATURES
- The 5' region of exon 1b encodes for an alternative promotor
TEMPORAL REGULATION
- nd
TECHNIQUE
- northern
ACCESSION
- M26958, M26959, M26960
SOURCE
- genomic
5' SCORE
- -16.10
3' SCORE
- -2.54
ACCEPTOR SITE
- ctggaacgaaag
EXON SEQUENCE
- 1 ggcctggttc gcaaagaagc tgacttcaga gggggaaact ttcttctttt aggaggcggt tagccctgtt ccacgaaccc aggagaactg ctggccagat taattagaca ttgctatggg agacgtgtaa acacactact tatcattgat gcatatataa aaccatttta ttttcgctat tatttcagag gaagcgcctc tgatttgttt cttttttccc tttttgctct ttctggctgt gtggttttgg agaaagcaca gttggagtag ccggttgcta aataa
DONOR SITE
- gtaagtgctgagaggc
5' EXON
- 0 ctgtttcttc taagcaaaag atctccctct ctctagccga tgctccccac tcagttcatc ccgggaatgg gccagggagg aaccttcatg catcggcccc gagctgccag gcgaccttcg ggctccttaa attcacaggc caacagcccg cgtcctctcc gcgcaggctc cccggttgcc cgcggtcccc ggcccagctc cttggcctcc tcctcgtcgg tccgcccctg gtggtcttgg cgcccgctcg tccagctcgg cgcgccgggg accgccggct gcccggggca gtccgcacgc cctcggggat ctcggctccc ggatccgccg cgccggcagg agccggccgg gcctggaggg agcaagcgga tcgccacgcc cccggcacgg atgggcgaca gggccgggct ccggggtggg gctcggcaga gctcctgaca gctccggggt cggcagcggg gaggggggag ctccgccgct cgccgctcat tcccggctcg gggctcccct ccactcgctc gggcgggcgc ggggcccgtt gcgccgcccg tcgcgccccc gccccccgcg cgcccgcccg ccagcccgcc cgtgcccgct tcgccccgcg cgcgttccta gggcgccacc tctttgcgac tagctcactt ctagcaggtt tgcctcggag cgtgtgaaca ttcctccgct cggttttcaa ctcgcctcca acctgcggcc cggccagcat gtctctccgc ccgtgaagcg ggctcgcctc cctggctccg gctgccacta acgacccgcc ctcgcccgac ctggccctcc tgatcgacga cacacgcact tgaaacttgt tctcagggtg tgtggaatca actttccgga agcaaccagc ccaccagagg ag
3' EXON
- 0 gtcccgagcg cgagcggaga cgatgcagcg gagactggtt cagcagtgga gcgtcgcggt gttcctgctg agctacgcgg tgccctcctg cgggcgctcg gtggagggtc tcagccgccg cct
DISEASE
- data support the idea that the HHM syndrome is mediated by a secreted tumor factor with biological activity similar to PTH: PTHrP
COMMENTS
- PTHrP is an example of genes producing mRNAs with heterogeneous 5'- and 3'- regions as well as multiple promoter sites. ;; the seq of item 15 may include some errors
REVISION
- created on 970618