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NUMBER

HS_A5_00_00_G_U_Y_m0078

DEFINITION

c-erbB3 gene, exon S

REFERENCE

Katoh, M., Yazaki, Y., Sugimura, T., and Terada, M., c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. Biochem Biophys Res Commun, 1993. 192: p. 1189-97.

EXPRESSION

minor form, higest expression in MKN45 and MKN28 cells

REGULATORY FEATURES

stop codon, encodes truncated, soluble form

TEMPORAL REGULATION

nd

TECHNIQUE

RACE, northern blot

ACCESSION

S61953

SOURCE

genomic DNA

5' SCORE

NA

3' SCORE

NA

ACCEPTOR SITE

na

EXON SEQUENCE

3 GTCAGTTCCC GATGGTTCCT TCTGGCCTCA CCCCTCAGCC AGCCCAAGAC TGGTACCTCC TTGATGATGA CCCAAGACTG CTCACTCTAA GTGCCTCTTC CAAGGTGCCT GTCACCTTGG CCGCTGTCTA Aaggtccatt gctccctaag caatagaggg cccccagtag gggagctagg ggcatctgct ccagggaaag gaaccctgtg tccttgtggg gctggagtca gagctggatc tgttaaccgt ttttctaatt tcaaagtaca gtgtaccgga ggccaggcct gatggcttac acctgtaatc ccagcatttt gggaggccaa ggagggcaga tcacttgaga tcaggagttt gagaccagcc tggccaacat ggcgaaaccc tgtctctact aaaaatacaa aaaaataaaa taaaataaaa aattagctgg c

DONOR SITE

na

5' EXON

1 TCTATAATGG TTAACTTTGT GCTTTTCATC GGCATCATCA TCATCCTTGT ACAGAAGCTG CAGTCCCCAG ACATGGGAGG CAACGAGTCC AGCATCTACT T

3' EXON

na

DISEASE

secreted form created by exon S usage involved in gastric cancer

COMMENTS

the exon uses an alternative 5' splice site and terminates with polyA

REVISION

created on 971128