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NUMBER

DM_CA_MT_DE_G_D_N_m0523-C

DEFINITION

tyrosine hydroxylase, exon C

REFERENCE

Birman, S., Morgan, B., Anzivino, M., and Hirsh, J., A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing. J Biol Chem, 1994. 269: p. 26559-67.

EXPRESSION

major form in larva and adult, skipping of exon characteristic for central nervous system

REGULATORY FEATURES

nd

TEMPORAL REGULATION

expression increases in adult

TECHNIQUE

technique

ACCESSION

U14395

SOURCE

genomic DNA

5' SCORE

4.62

3' SCORE

0.10

ACCEPTOR SITE

atgattttaaag

EXON SEQUENCE

3 ACGATTCCCT GGAAGATTGC ATTGTGCAGG CTCAGGAGCA CATTCCCTCC GAGCAAGATG TGGAGCTCCA GGACGAGCAT GCCAATCTGG AGAACCTGCC CTTGGAGGAA TATGTTCCAG

DONOR SITE

gttaat

5' EXON

1 AATGGCTATC CATCCCGCCG TCGCAGCCTG GTGGATGATG CCCGTTTCGA GACCCTGGTG GTCAAGCAGA CCAAACAAAC CGTCCTCGAG GAGGCCCGCA GCAAGGCAAA TG

3' EXON

3 ATTACGGTCT CACCGAGGAC GAGATTTTGT TGGCCAATGC CGCCTCCGAA TCCTCGGATG CCGAGGCTGC CATGCAGAGT GCCGCTTTGG TGGTCCGCCT CAAGGAGGGC ATCTCCTCCT TGGGTCGCAT CCTCAAGGCC ATCGAAACCT TCCACGGCAC CGTCCAGCAT GTGGAGTCCC GTCAGTCGCG CGTGGAGGGC GTGGACCACG ATGTCCTCAT CAAGTTGGAC ATGACCCGTG GCAATCTGCT GCAGCTGATC CGCTCCCTCA GGCAGTCGGG CTCCTTCAGC AGCATGAATC TGATGGCCGA CAATAACTTG AATGTCAAGG CTCCGTGGTT CCCCAAGCAC GCCTCCGAAT TGGATAACTG CAACCATCTG ATGACCAAGT ACGAGCCCGA TTTGGACATG AACCACCCCG GATTCGCCGA CAAGGTATAC CGCCAGCGTC GCAAGGAAAT TGCCGAGATC GCATTCGCCT ACAAGTACGG AGACCCGATC CCATTCATCG ACTACTCCGA TGTGGAGGTC AAGACCTGGC GCTCGGTGTT CAAGACCGTT CAGGATCTGG CTCCCAAGCA CGCCTGTGCC GAGTACCGGG CCGCCTTCCA GAAGCTCCAG GATGAGCAGA TCTTCGTGGA GACCCGTCTG CCCCAGTTGC AGGAGATGTC CGACTTTCTG CGCAAGAACA CCGGATTCTC TCTCCGTCCT GCCGCCGGTC TTTTGACTGC CCGGGACTTC CTTGCCTCCT TGGCCTTCCG CATCTTCCAG AGCACCCAGT ATGTGCGCCA CGTTAACTCA CCATACCACA CCCCCGAGCC

DISEASE

COMMENTS

exon always used together with exon D (M0523-D)

REVISION

created on 971128