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NUMBER
- DV_ME_NE_DE_G_D_N_m0944-c
DEFINITION
- para, exon c
REFERENCE
- Thackeray, J.R., and Ganetzky, B., Conserved alternative splicing patterns and splicing signals in the drosophila sodium channel para. Genetics, 1995. 141: p. 203-214.
EXPRESSION
- predominantly neuronal
REGULATORY FEATURES
- exon part of voltage sensor motif, T->H exchange from exon c to d changes charge that might be involved in voltage dependance of channel gating
TEMPORAL REGULATION
- exon used predominantly in embryo (95%)
TECHNIQUE
- cloning
ACCESSION
- U26722
SOURCE
- genomic DNA
5' SCORE
- -12.75
3' SCORE
- 2.97
ACCEPTOR SITE
- gccaatttgcag
EXON SEQUENCE
- 1 ctgcgtgtat tcaaattggc caaatcatgg ccaacgttaa atttactcat atcgataatg ggtcgcactg tcggcgctct gggcaatctg accttcgtct tatgcattat aatcttcata tttgctgtaa tgggcatgca gctgtttggc aaaaactaca cag
DONOR SITE
- gtattatt
5' EXON
- 1 ttcttcaccg ccacatttgc aattgaggcc acgatgaaac tgatggccat gagtcccaaa tactatttcc aggagggatg gaacatcttt gatttcataa ttgtcgccct ctcactgctc gagctgggcc tcgagggcgt ccagggtcta tccgtattgc gttcgtttcg tttg
3' EXON
- 1 gttcttaacc ttttcttagc cttgcttttg tcaaattttg gctcatctag tttatcagca ccgactgccg acaatgatac caacaaaata gccgaggcct ttaatcgtat cggtcgtttt aaaagttggg ttaagcgtaa tgttgctgat tgtttcaagt taatacgtaa caaattgaca aatcaaataa gtgatcaacc ttcaggtgag aggatcaacc agatcagttg gatttggagc gaag
DISEASE
-
COMMENTS
- developmental regulation discussed in: Thackeray, J.R., and Ganetzky, B., Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J Neurosci, 1994. 14: p. 2569-2578. ;; organism: drosophila virilis ;; exon mutually exclusive to m0944-d ;; complete exon-intron structure known
REVISION
- This entry is created on 970316