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NUMBER

DV_ME_NE_DE_G_D_N_m0944-d

DEFINITION

para, exon d

REFERENCE

Thackeray, J.R., and Ganetzky, B., Conserved alternative splicing patterns and splicing signals in the drosophila sodium channel para. Genetics, 1995. 141: p. 203-214.

EXPRESSION

expression pattern

REGULATORY FEATURES

exon part of voltage sensor motif, T->H exchange from exon c to d changes charge that might be involved in voltage dependance of channel gating

TEMPORAL REGULATION

exon used in adult (20%) , not in embryo

TECHNIQUE

cloning

ACCESSION

U26722

SOURCE

genomic DNA

5' SCORE

-24.07

3' SCORE

5.08

ACCEPTOR SITE

cccgttgcgtctatag

EXON SEQUENCE

1 ctgcgtgtat tcaaattggc caaatcttgg ccaacactta atttactcat ttcgattatg ggccgcacca tgggcgcttt gggtaatctg acatttgtac tttgcattat catcttcatc tttgcggtga tgggaatgca actgttcgga aagaactatc atg

DONOR SITE

gtaagtcc

5' EXON

1 ttcttcaccg ccacatttgc aattgaggcc acgatgaaac tgatggccat gagtcccaaa tactatttcc aggagggatg gaacatcttt gatttcataa ttgtcgccct ctcactgctc gagctgggcc tcgagggcgt ccagggtcta tccgtattgc gttcgtttcg tttg

3' EXON

1 gttcttaacc ttttcttagc cttgcttttg tcaaattttg gctcatctag tttatcagca ccgactgccg acaatgatac caacaaaata gccgaggcct ttaatcgtat cggtcgtttt aaaagttggg ttaagcgtaa tgttgctgat tgtttcaagt taatacgtaa caaattgaca aatcaaataa gtgatcaacc ttcaggtgag aggatcaacc agatcagttg gatttggagc gaag

DISEASE

COMMENTS

developmental regulation discussed in: Thackeray, J.R., and Ganetzky, B., Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J Neurosci, 1994. 14: p. 2569-2578. ;; organism: drosophila virilis ;; exon mutually exclusive to m0944-c ;; complete exon intron structure known

REVISION

This entry is created on 970316