Data Modifying Form for the Entry: 0278
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
CRK II
Give the Full Reference, Including Title:
@92334347 Matsuda, M., Tanaka, S., Nagata, S., Kojima, A., Kurata, T., and Shibuya, M., Two species of human CRK cDNA encode proteins with distinct biological activities. Mol Cell Biol, 1992. 12: p. 3482-9.
Expression Pattern (e.g., expressed in muscle):
nd
Regulatory Features (e.g., encodes stop codon, phosphorylation):
frame shift, deletes an SH3 domain. This deletion changes tumorgenicity
Temporal Regulation:
nd
Technique Used to Determine the Expression Pattern:
cloning, protection
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
gtaaccagga gggttcccac ccacagccac tgggcccccc ggagcctggc ccctatgccc aacccagcgt caacactccg ctccctaacc tccagaatgg gcccatatat gccagggtta tccagaagcg agtccccaat gcctacgaca agacagcctt ggctttggag
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
atggcgggca acttcgactc ggaggagcgg agtagctggt actgggggcg gttgagtcgg caggaggcgg tggcgctgct gcagggccag cggcacgggg tgttcctggt gcgggactcg agcaccagcc ccggggacta tgtgctcagc gtctcagaga actcgcgcgt ctcccactac atcatcaaca gcagcggccc gcgcccgccg gtgccaccgt cgcccgccca gcctccgccc ggggtgagcc cctccagact ccgaatagga gatcaagagt ttgattcatt gcctgcttta ctggaattct acaaaataca ctattgggac actacaacgt tgatagaacc agtttccaga tccaggcagg gtagtggagt gattctcagg caggaggagg cggagtatgt gcgagccctc tttgacttta atgggaatga tgaggaagat cttcccttta agaaaggaga catcttgaga atccgggaca agcctgaaga gcagtggtgg aatgcggagg acagcgaagg caagagaggg atgattccag tcccttacgt cgagaagtat agacctgcct ccgcctcagt atcggctctg attggag
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
gtcggtgagc tggtaaaggt tacgaagatt aatgtgagtg gtcagtggga aggggggtgt aatggcaaac gaggtcactt cccattcaca catgtccgtc tgctggatca acagaatccc gatgaggact tcagctgagt atagttcaac agttttgctg acagatggga acaatctttt tttttttttt ttccaactgc catctataca attttcttac agatgtcaaa agcagtctag tttatataag cattctgtta cctgtgatat tttttagact gaactgctcc attcctagtc ttaattacca tattcagggt acgaactgga gggcttgtgt gttagcttct gaattggcaa ttggaggcgg tagtggtcgt gcctgtgtgt atcagaaggg ata
Disease or Abnormal Processing Described?:
nd
Comments:
tumorgenicity was assayed in nude mice
Revision (will be updated automatically!):
This comment is added on 970314
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nakai@imcb.osaka-u.ac.jp