Data Modifying Form for the Entry: 0358
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
tpr, translocated promoter region
Give the Full Reference, Including Title:
@92195670 Mitchell, P.J., and Cooper, C.S., Nucleotide sequence analysis of human tpr cDNA clones. Oncogene, 1992. 7: p. 383-8.
Expression Pattern (e.g., expressed in muscle):
skipping and inclusion of this exon in most cell lines, in HL60 promyelocytic cell line only inclusion
Regulatory Features (e.g., encodes stop codon, phosphorylation):
stop codon
Temporal Regulation:
nd
Technique Used to Determine the Expression Pattern:
cloning and PCR
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
cttgtagaat tacttttttc ataccagtta
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
caagttacag atttgcgatc acaaaatacc aaaatttcta cccagctaga ttttgcttct aaacgtta
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
tgaaatgctg caagataatg ttgaaggata tcgtcgagaa a
Disease or Abnormal Processing Described?:
gene is implicated in activation of met and raf oncogenes
Comments:
Revision (will be updated automatically!):
This comment is added on 970314 ;; gene name was corrected (trp -> tpr) in item 2
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