Data Modifying Form for the Entry: 0545-HUM
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
type II collagen gene, exon 2, human
Give the Full Reference, Including Title:
@91358489 Metsaranta, M., Toman, D., de Crombrugghe, B., and Vuorio, E., Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing. J Biol Chem, 1991. 266: p. 16862-9.
Expression Pattern (e.g., expressed in muscle):
in older fetus exon 2 is used in most non-chondrogenic tissues
Regulatory Features (e.g., encodes stop codon, phosphorylation):
might have a morphogenetic role in development
Temporal Regulation:
expressed in prechondrogenic cells, during maturation of chondrocytes exon is no longer expressed,
Technique Used to Determine the Expression Pattern:
RNA in situ
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
aggaggctgg cagctgtgtg caggatgggc agaggtataa tgataaggat gtgtggaagc cggagccctg ccggatctgt gtctgtgaca ctgggactgt cctctgcgac gacataatct gtgaagacgt gaaagactgc ctcagccctg agatcccctt cggagagtgc tgccccatct gcccaactga cctcgccact gccagtg
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
atgattcgcc tcggggctcc ccagacgctg gtgctgctga cgctgctcgt cgccgctgtc cttcggtgtc agggccagga tgtcc
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
ggcaaccagg accaaag
Disease or Abnormal Processing Described?:
Comments:
complete gene structure known, expression determined in: <<@95383733 Lui, V.C.H., Ng, L.J., Nicholls, J., Tam, P.P.L., and Cheah, K.S.E., Tissue specific and differential expression of alternatively spliced alpha1(II) collagen mRNAs in early human embryos. Develop. Dynamics, 1995. 203: p. 198-211.>>
Revision (will be updated automatically!):
This entry is modified on 970316; title line (item 2) was modified ;; item 15 was modified by M25698
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