Data Modifying Form for the Entry: 0558-a3
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
ASF-2
Give the Full Reference, Including Title:
@91309149 Ge, H., Zuo, P. and Manley, J.L. (1991) Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell 66(2): 373-82.
Expression Pattern (e.g., expressed in muscle):
nd
Regulatory Features (e.g., encodes stop codon, phosphorylation):
frameshift, changes a downstream SR domain into a hydrophobic domain
Temporal Regulation:
nd
Technique Used to Determine the Expression Pattern:
cloning
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
TTCTGTCTAT CCAATAG
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
GGGGGTGGAG GTGGCGGAGC TCCCCGAGGT CGCTATGGCC CCCCATCCAG GCGGTCTGAA AACAGAGTGG TTGTCTCTGG ACTGCCTCCA AGTGGAAGTT GGCAGGATTT AAAGGATCAC ATGCGTGAAG CAGGTGATGT ATGTTATGCT GATGTTTACC GAGATGGCAC TGGTGTCGTG GAGTTTGTAC GGAAAGAAGA TATGACCTAT GCAGTTCGAA AACTGGATAA CACTAAGTTT AGATCTCATG AG
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
GGAGAAACTG CCTACATCCG GGTTAAAGTT GATGGGCCCA GAAGTCCAAG TTATGGAAGA TCTCGATCTC GAAGCCGTAG TCGTAGCAGA AGCCGTAGCA GAAGCAACAG CAGGAGTCGC AGTTACTCCC CAAGGAGAAG CAGAGGATCA CCACGCTATT CTCCCCGTCA TAGCAGATCT CGCTCTCGTA CATAAGATGA TTG
Disease or Abnormal Processing Described?:
na
Comments:
no expression of this isoform could be detected in Northern blot, gene structure of flanking exons not clear
Revision (will be updated automatically!):
created on Apr 18, 1998
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Alternative Splicing Database Home Page
nakai@imcb.osaka-u.ac.jp