Data Modifying Form for the Entry: 0691
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
Evi-1
Give the Full Reference, Including Title:
@90295289 Bordereaux, D., Fichelson, S., Tambourin, P., and Gisselbrecht, S., Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs. Oncogene, 1990. 5: p. 925-7.
Expression Pattern (e.g., expressed in muscle):
the two forms are expressed in virus transformed cells as well as in kidney
Regulatory Features (e.g., encodes stop codon, phosphorylation):
exon deletion results in deletion of two of the 10 zinc fingers
Temporal Regulation:
nd
Technique Used to Determine the Expression Pattern:
RNase protection, northern
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
gtgagggcaa gaaccatttt gcggcaggtg gattttttgg ccaaggcatt tcacttcctg gaacgccagc tatggataaa acgtccatgg ttaatatgag tcatgccaac ccgggccttg ctgactattt tggcgccaat aggcatcctg ctggtcttac ctttccaaca gctcctggat tttcttttag cgttcctggt ctgtttcctt ccggcttgta ccacaggcct cctttgatac ctgctagttc tcctgttaaa ggactatcaa gtactgaaca gacaaacaaa agtcaaagtc ccctcatgac acatcctcag atactgccag ctacacagga tattttgaag gcactatcta aacacccatc tgtaggggac aataagccag tggagctcca gcccgagagg tcctctgaag agaggccctt tgagaaaatc agtgaccagt cagagagtag tgaccttgat gatgtcagta caccaagtgg cagtgacctg gaaacaacct cgggctctga tctggaaagt gacattgaaa gtgataaaga gaaatttaaa gaaaatggta aaatgttcaa agacaaagta agccctcttc agaatctggc ttcaataaat aataagaaag aatacagcaa tcattccatt ttctcaccat ctttagagga gcagactgcg gtgtcaggag ctgtgaatga ttctataaag gctattgctt ctattgctga aaaatacttt ggttcaacag gactggtggg gctgcaagac aaaaaagttg gagctttacc ttacccttcc atgtttcccc tcccattttt tccag
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
tcagttttca aacctttgcc gtcataagcg catgcatgct gattgcagaa cccaaatcaa gtgcaaagac tgtggacaaa tgttcagcac tacgtcttcc ttaaataaac acaggaggtt tt
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
cattctctca atcaatgtac ccatttcctg atagagactt gagatcgtta cctttgaaaa tggaacccca atcaccaggt gaagtaaaga aactgcagaa gggcagctct gagtccccct ttgatctcac cactaagcga aag
Disease or Abnormal Processing Described?:
proviral integration (linkage to Evi-1) results in expression of the two isoforms and myeloid leukemia
Comments:
Revision (will be updated automatically!):
This comment is added on 970314
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Alternative Splicing Database Home Page
nakai@imcb.osaka-u.ac.jp