Data Modifying Form for the Entry: 0966-1
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
human parathyroid-hormone-related protein ( PTHrP ) , exon 1b
Give the Full Reference, Including Title:
@89306685 Suva, L.J., Mather, K.A., Gillespie, M.T., Webb, G.C., Ng, K.W., Winslow, G.A., Wood, W.I., Martin, T.J., and Hudson, P.J., Structure of the 5' flanking region of the gene encoding human parathyroid- hormone-related protein (PTHrP). Gene Vol 77:95-105
Expression Pattern (e.g., expressed in muscle):
PTHrP is produced in Cancers associatid with the HHM
Regulatory Features (e.g., encodes stop codon, phosphorylation):
The 5' region of exon 1b encodes for an alternative promotor
Temporal Regulation:
nd
Technique Used to Determine the Expression Pattern:
northern
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
ggcctggttc gcaaagaagc tgacttcaga gggggaaact ttcttctttt aggaggcggt tagccctgtt ccacgaaccc aggagaactg ctggccagat taattagaca ttgctatggg agacgtgtaa acacactact tatcattgat gcatatataa aaccatttta ttttcgctat tatttcagag gaagcgcctc tgatttgttt cttttttccc tttttgctct ttctggctgt gtggttttgg agaaagcaca gttggagtag ccggttgcta aataa
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
ctgtttcttc taagcaaaag atctccctct ctctagccga tgctccccac tcagttcatc ccgggaatgg gccagggagg aaccttcatg catcggcccc gagctgccag gcgaccttcg ggctccttaa attcacaggc caacagcccg cgtcctctcc gcgcaggctc cccggttgcc cgcggtcccc ggcccagctc cttggcctcc tcctcgtcgg tccgcccctg gtggtcttgg cgcccgctcg tccagctcgg cgcgccgggg accgccggct gcccggggca gtccgcacgc cctcggggat ctcggctccc ggatccgccg cgccggcagg agccggccgg gcctggaggg agcaagcgga tcgccacgcc cccggcacgg atgggcgaca gggccgggct ccggggtggg gctcggcaga gctcctgaca gctccggggt cggcagcggg gaggggggag ctccgccgct cgccgctcat tcccggctcg gggctcccct ccactcgctc gggcgggcgc ggggcccgtt gcgccgcccg tcgcgccccc gccccccgcg cgcccgcccg ccagcccgcc cgtgcccgct tcgccccgcg cgcgttccta gggcgccacc tctttgcgac tagctcactt ctagcaggtt tgcctcggag cgtgtgaaca ttcctccgct cggttttcaa ctcgcctcca acctgcggcc cggccagcat gtctctccgc ccgtgaagcg ggctcgcctc cctggctccg gctgccacta acgacccgcc ctcgcccgac ctggccctcc tgatcgacga cacacgcact tgaaacttgt tctcagggtg tgtggaatca actttccgga agcaaccagc ccaccagagg ag
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
gtcccgagcg cgagcggaga cgatgcagcg gagactggtt cagcagtgga gcgtcgcggt gttcctgctg agctacgcgg tgccctcctg cgggcgctcg gtggagggtc tcagccgccg cct
Disease or Abnormal Processing Described?:
data support the idea that the HHM syndrome is mediated by a secreted tumor factor with biological activity similar to PTH: PTHrP
Comments:
PTHrP is an example of genes producing mRNAs with heterogeneous 5'- and 3'- regions as well as multiple promoter sites. ;; the seq of item 15 may include some errors
Revision (will be updated automatically!):
created on 970618
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