Data Modifying Form for the Entry: m0944-d
Name of the Submitter:
Species:
abbreviation
Splicing Mechanism:
CA
cassette
ME
mutually exclusive exons
A3
alternative 3' splice site
A5
alternative 5' splice site
AE
alternative 3' exon with polyA
RI
retained intron
UU
other or unknown
Tissue:
abbreviation
Temporal (developmental) Regulation:
DE: yes / NO: no / UU: unknown
Sequence Information:
C: cDNA / G: genomic DNA / U: unknown
Promoter Use:
F: follows / D: different / U: unknown
Disease Involvement:
Y: yes / N: no / U: unknown
4 Digits Internal Number:
Name of the Gene:
para, exon d
Give the Full Reference, Including Title:
@96042905 Thackeray, J.R., and Ganetzky, B., Conserved alternative splicing patterns and splicing signals in the drosophila sodium channel para. Genetics, 1995. 141: p. 203-214.
Expression Pattern (e.g., expressed in muscle):
expression pattern
Regulatory Features (e.g., encodes stop codon, phosphorylation):
exon part of voltage sensor motif, T->H exchange from exon c to d changes charge that might be involved in voltage dependance of channel gating
Temporal Regulation:
exon used in adult (20%) , not in embryo
Technique Used to Determine the Expression Pattern:
cloning
Accession number of the exon:
Genomic or cDNA?:
Give 12 nucleotides of the 3' splice site:
Give the Sequence of the Alternatively-spliced Exon:
Reading Frame:
unknown
1st
2nd
3rd
ctgcgtgtat tcaaattggc caaatcttgg ccaacactta atttactcat ttcgattatg ggccgcacca tgggcgcttt gggtaatctg acatttgtac tttgcattat catcttcatc tttgcggtga tgggaatgca actgttcgga aagaactatc atg
Give 6 nucleotides of the 5' splice site:
Give the Sequence (or accession number) of the 5' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
ttcttcaccg ccacatttgc aattgaggcc acgatgaaac tgatggccat gagtcccaaa tactatttcc aggagggatg gaacatcttt gatttcataa ttgtcgccct ctcactgctc gagctgggcc tcgagggcgt ccagggtcta tccgtattgc gttcgtttcg tttg
Give the Sequence (or accession number) of the 3' Common Exon:
Reading Frame:
unknown
1st
2nd
3rd
gttcttaacc ttttcttagc cttgcttttg tcaaattttg gctcatctag tttatcagca ccgactgccg acaatgatac caacaaaata gccgaggcct ttaatcgtat cggtcgtttt aaaagttggg ttaagcgtaa tgttgctgat tgtttcaagt taatacgtaa caaattgaca aatcaaataa gtgatcaacc ttcaggtgag aggatcaacc agatcagttg gatttggagc gaag
Disease or Abnormal Processing Described?:
Comments:
developmental regulation discussed in: <<@94238327 Thackeray, J.R., and Ganetzky, B., Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J Neurosci, 1994. 14: p. 2569-2578.>> ;; organism: drosophila virilis ;; exon mutually exclusive to m0944-c ;; complete exon intron structure known
Revision (will be updated automatically!):
This entry is created on 970316
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